Changes in Frank and Ritas Relationship :: Educating Rita Relationships Plays Essays

Changes in Frank and Rita's Relationship Referring closely to Scenes 6 & 7 in Act 2, discuss the changes seen in Frank and Rita's relationship. In this essay I will be referring closely to Scenes 6 & 7 in Act 2. I will be discussing the changes in Frank’s and Rita’s relationship, and comparing their relationship â€Å"now† as to what it used to be in the beginning of the play. Rita & Frank are the two main or, only characters in the play. This is a powerful and smart way to let the audience or reader to get to know our two characters, their feelings, emotions and thoughts. The audience can see and tell the difference in the characters social status straight away. Frank is a professor in a university, teaching English literature – in his late forties. He is an alcoholic – loves to drink, he has a girlfriend, but this relationship that he’s in is going like all others; failure. He is the type of person that drinks in order to forget his troubles and worries – drink makes him happy, even though it is killing him and his relationship just as well as his career: â€Å"Yes, I probably shall go to the pub afterwards. I shall need to go to the pub afterwards. I shall need to wash away the memory of some silly woman’s attempts to get into the mind of Henry James or whoever it is we’re supposed to study on this course†¦Oh God, why did I take this on? †¦Yes I suppose I did take it on to pay for the drink† This is a conversation that Frank has with his girlfriend over the phone, it immediately goes to prove that he doesn’t really care about his career and the only thing that is on his mind is alcohol. Rita on the other hand is a twenty-six year old, working class woman who wants to get an education, and by doing that she believes that she is going to â€Å"discover† herself. She is in a relationship; she’s been living with her partner for six years. She also wants to learn how to speak â€Å"proper† English. In the beginning of the play Rita and Frank are getting to know each other, and they have nothing more than a â€Å"teacher-student† relationship, although throughout the play we can see that they get to know each other better, and they gain more respect for each other. Everything starts to change when Rita goes off to summer school. When she comes back from summer school Frank is surprised by her appearance

Chlamydia :: essays research papers

Chlamydia Chlamydia is the most common sexually transmitted infection in the United States. It strikes about 4 million people a year in the U.S.. 100,000 women become infertile each year from a pelvic inflammatory disease (PID), which plugs up or scars the filopian tubes, so the egg can’t reach the uterus. 45% of sexually active teenagers are exposed to the disease at least once. Clamydia is caused by a bacterium, named chlamydia trachomatis. The pathogen enters the body through sexual activity, or when some comes in contact with the infected persons bodily fluids, such as blood, semen, or vaginal fluid. Chlamydia is often unnoticed because the symptoms are often inconspicuous or not present at all. When symptoms do arise, in men, it is usually a clear or white discharge from the penis or a swelling of the testicles, which can lead to infertility if left untreated. 75% of women with the disease show no symptoms. In those that do, it is usually a yellow discharge from the urethra, painful urination, or painful sex. Â ½ of all cases of pelvic inflammatory disease, which leads to an ectopic pregnancy in pregnant women, is caused by chlamydia. Ectopic pregnancy is the leading cause of death of pregnant teens in the inner city and poor neighborhoods. Chlamydia also causes conjunctitis. This is a swelling of the eyes which can lead to blindness. The bacteria also can lead to pneumonia. Although it is the most easily treated STI, most people in danger won’t get checked until complications show, and that is why the disease is spread so much. It takes about three weeks for most people to see symptoms. In that time, they have sexual contact with others and not know they are spreading it. This process goes on and on and some day it could turn into an epidemic. This is why it is called the "silent epidemic". Chlamydia s simple to cure. Physicians prescribe a one day course of an antibiotic, azithromycin, and it’s gone.

Data Encryption Essay -- Encrypting Text Essays

Data Encryption I. What is Data Encryption? Data encryption describes the transformation of plain text into a different format that is meaningless read by human eye without being decrypted, so called cipher text, in order to prevent any unauthorized party to obtain information from the document. According to the Webster dictionary, â€Å"cryptography is the practice and study of data encryption and decryption - encoding data so that it can only be decoded by specific individuals.† Crypto is derived from the Greek word kruptos, to hide, from kruptein, which means hidden and secret. In the old days, people attempted to withhold certain information as their private possession, and to hide the information from exposures to the public. There were many different methods they used in order to conceal this information, such as substituting part of the information by symbols, numbers or pictures for different reasons to protect their secrets. With the advancement of human intellects and modern computing powers, cryptosystems are invented as systems used to encrypt and decrypt data electronically. By deploying sophisticated mathematical algorithm into the process, it combines the original data with one or more a serial of numbers or strings of characters, as known as â€Å"k eys† privately and solely owned by sender and/or recipient. Cipher text is generated as an end result of this process. The computer aided data encryption is much more accurate, efficient and reliable compared to the ancient methods. Encryption has a very long history,1 which can be traced back to about 1900 B.C. Cryptography was first used in the form of hieroglyphic inscription by an ... ...partment of Commerce, National Institute of Standards and Technology, , Docket Number 000929280-1201-02 2. Federal Information, Processing Standards Publication 197, Announcing the Advanced Encryption Standards, (November 26, 2001) 3. Jim Reavis, Network World Fusion, , (July 30, 2001) 4. Joan Daemen,Vicent, Rijmen, The RijnDael Block Cipher, AES Proposal, (2000) 5. Lou Breit, Security Demands Lead to Strong Measures, Enterprise Networking Magazine, (December, 2002) 6. SANS Institute, History of Encrytion, Information Security Reading Room, 2001 7. Think Quest Team, Data Encryption, History, Legal and Ethics, (Copyright@1999) 8. Andrew S. Tanenbaum, Computer Networks, Prentice Hall PTR, page 479-512, Third Edition, (1996)

Revivalism Essay

â€Å"Revivalism is an authentic Afro-Christian religious folk form that evolved during the eighteenth to nineteenth century. Initially, it was the native Baptist Christians who joined forces with the Moravians, and other non-conformist churches to become the forerunners of the movement. However, Jamaica was said to have experienced a religious movement called the Great Revival in 1861, which saw the incorporation of much more African retention in the movement. Pocomania is more African in form while Zion is more Christian oriented. † [1] Upon preparing to embark this journey, I was a bit disgruntled that I had to wake up in the wee hours of the morning to go this â€Å"Watt Town† excursion, but I still approached with a open mind, though I had an idea of what to expect, seeing that I was already acquainted with quite a few Revivalists. Honestly I expected it to be a waste of time, but upon seeing the fellowship of my friends, while waiting on the buses which were scheduled to take us on our journey it got easier and easier, we engaged in jokes and hymns we swore were Revivalist hymns but Mr. Grey quickly busted our bubble and told us that those hymns were Pentecostal. We were greeted by a semi-pleasant but slow bus driver, but the vibe in our bus quickly took our minds off the length of the journey. I view Revivalists as highly religious people who are in tune with spirits with from various realms, known as Heaven, Earth and Ground spirit realms, I met with a lot of different Revivalists, but what I found rather interesting was the fact that the core of what they were saying were similar but they were also many subtle differences, For example I met with a man, whose name is Joseph Whitter, of the Olivette Seventh day church. nd he seemed to be quite respected in the church community, he blatantly stated at the beginning of the conversation that, â€Å"Revivalism is the only way to be saved†, we had a long drawn out discussion on what are my personal views on religion and the opening statement he made, where I told him that I strongly disagree with that statement and I believe that there is only one God and peace and love is the ultimate goa l, which everyone should try to achieve, no matter what religion one identifies with. I then met with Miss. Barbara Harper of the same church, Olivette Seventh day church, and she stated that people should go to any church they want to go to and do anything that is truly pleasing to God, when I mentioned what her church brother thought about the same thing, she said that there is no one way to get to heaven and that people spend more of their time in competition with other denominations and religions rather than giving praises to the most high. I laughed a bit and I was in total agreement with her statement. We then started to talk about her life, and how she was before she identified that Revivalism was for her, I could see that the movement actually helped her and improved her life, before moving on I thanked her for being so honest and reasoning with me, telling her that I would listen to her talk any day for she had a liberal and open mind and I absolutely hated radical minded people, who try to force their doctrines and beliefs down peoples throats. When we finally arrived at Watt Town, after our extra long journey I had no idea of what I was about to witness, the site was like nothing I had seen before, I was greeted by what had seemed to be hundreds of people, I discovered that Watt Town was having what had seemed like an inter -church convention. I saw children from various schools and young adults like our selves there to see this feat. One of the first things I noticed about the Revivalists was they were wearing different uniforms in different styles and colours, I wondered and asked why were they dressed like this and a kind lady told me that each church was represented by different uniforms. The seal is the focal point of the church; this is where the angels are believed to manifest themselves. This is the most sacred area of the ground and is a welcoming tool. The seal is a dominant feature in all revivalist churches because the seal encourages spirits which come and possess the members, enabling them to carry out their works of healing and worship. It is advised that one should walk around the seal three times to pay respect to the Tribune God. Some seals can be seen with silver coins in them, this is payment to the spirits for their help. The flags and banners we saw at the front play a very important role in the revivalism. A tall pole usually marks a revival ground. The flags on the pole are used to attack passing spirits, the attraction of spirits is very important to revivalism because they believe in many spirits and that they can be appeased or summoned to assist in their day-to-day lives. Each banner has its own purpose. Green means anything of nature, Blue and white means peace, pink love and red stands for the blood of Jesus. Upon venturing to the top of the structure, some pebbles started to rain from a roof top, some hitting my head, not understanding anything about what was going on yet, I didn’t take kindly to this, that confused me a bit more than I already was. When a group of us finally got to the top we noticed the different worship circles/prayer group, and I was pleased by some as I saw some circles which were mixed with members of different churches, this showed me that pride was not an issue and did not hinder worship, and the main goal, magnifying the most high, I stood in amazement right next to two worship circles and I heard various choruses, some I had heard before, some I had not, I was familiar with songs such as â€Å"Madda de great stone got to move† and â€Å"Rock oh! Rock holy, rock oh! Rock holy†. Being a musician I enjoyed this aspect of the excursion, identifying the keys and the chord progressions that would go with their simple but effective melodies. I noticed that even though their uniforms were different, they had many things in common, I noticed that many of them had head wraps with various pieces of stationery in the wraps, I laughed at this sight because I thought they were taking notes or something, but as I went on and I learned more I discovered that the pencils, rulers and scissors that I saw resting in their head wraps had special significance. The pencils and rulers signifies healing among the followers, the scissors were carried around by a specific set of people, known as the healers, who use the scissors to literally cut evil from around the persons being healed, as demonstrated to us by a young man named Otis. A few of the Revivalists were also seen carrying around a meter ruler, this was given to people who had been living a righteous life and who were slated to be married. We saw some people washing their face with sugar water, this was said to bring clearance and purity, the prayer shawl was said to represent the Tribe of Judah, as we learned that, like the Rastafarians there was a lot of African roots in Revivalism also, and they used red green and gold to identify with Ethiopia and Ghana. When I inquired about a lamp I saw an elderly woman carrying around, she said that the lamp also represents healing and spiritual light because revivalists don’t walk in the darkness. These healing symbols were brought from Africa with the slaves and became an integral part of the revivalist healing services. As a result the present day revivalist has maintained the practice. I asked some Revivalists of their actual occupations and from the replies I found out that they were either day workers, higglers or fishermen, (more than likely belonging to the lower class) I saw that this must have contributed to the scornful treatment by mainstream and middle/upper class Christians, They consider them to be highly superstitious, pagan, primitive and comical in ritual behaviors especially when they suspect them of practicing obeah. The disdain heaped on the lower class involved in revivalism can be traced to colonialism. Stratification was practiced on the plantation not only from the perspective of whites to none whites or but also among the blacks. The free slave felt himself above the house slave who felt they were superior to the field slaves and there was further stratification in that group depending on the gang to which they belong. Seaga, in his writings in the 1980’s explained that Revivalism also has different levels within its structure. There is the Leader who is the central figure of importance; below the leader are the armour bearer, shepherd boy and mother. The leader is never usually questioned on the reason for ritual observances. The ritualistic forms of Revivalism takes three major forms such as prayer meeting, street meeting and rituals for specific purposes for example tables, altars and baths. The meetings are usually opened to the public. Revivalism is divided into two groups, Zion and Pocomania, Pocomania is more African in form while Zion is more Christian oriented. they are referred to as 2 different spiritual groups the 60 and 61, the 60 spirit (Zion) are persons who believe in only one God, the Heavenly spirits, archangels, saints and angels. ho are viewed as firmly rooted and committed Christian. The 61 (Pocomania) spirit comprises of individuals who take commands from earth-bound spirits are the â€Å"Fallen Angels† (satanic powers), from God and from The Ground spirits are those of the human dead that are not biblically mentioned. I noticed that the people of the 60 spirit, look down the 61 in a way which gave me a feeling of segregation between both of the groups. I noticed that like other Christians, Revivalists also go on fasting sessions but they can’t just get up and fast they have to be ordered by the holy spirit. Also apart a Revivalists culture includes heavy usage of flowers they believe that when you place the flowers in water and go to sleep you dream see your future, whether it brings destruction or fortune. Some of my views on Revivalists were different after the trip, previously I thought that, Revivalists only went to church like other Christians and the worship was similar but I was mistaken, I also thought that they used instruments but I discovered that their bodies were their instruments, stomping and grunting to help them keep time and to provide percussive sounds. In my opinion the greatest gift Revivalists can give to the Jamaican culture, is their sense of unity, having being bashed for many many years, I saw that these people remained strong and stood firm for what they believe. That is what many religions and people of Jamaica need to survive through good times and bad, this was what I took away from the journey, and if I didn’t take anything else, I was glad I took this quality from the Revivalists, unity is strength and they will forever be a constant reminder of that value.

Pestel Anlysis Children Clothing

Report on environmental analysis & industry consolidations Introduction This report is about the importance of environmental analysis for the companies operating in the UK alcohol industry and what kind of tools is available for analysis. Also report will highlight the industry consolidation in the light of Greene King experience.Importance of environmental analysis This analysis is used to measure the internal (Strengths and weaknesses) and external (opportunities and threats) environment factors which affect companies in future and also help to make a strategy to compete environment influences. (J&S) If companies do not analyse their internal and external environment then it would affect the company’s growth and others will have a chance to get competitive advantages. â€Å"Boiled frog syndrome† is a good example for understanding the importance of environmental analysis. Lecture notes 1, 28. 09. 2005) Procedure There are three models for analysing the environment: (J &S) †¢ PESTEL analysis †¢ Industry life cycle †¢ Porter’s five forces frame work But in this report only two models will be used for scanning the environment. PESTEL analysis recognises the opportunities & threats for companies from internal or external environment and Porter’s Five Forces model recognises the source of competitor. Firstly this report will look at the PESTEL analysis and how could companies use this model for analysing the environment.PESTEL analysis is used to see the future impact of environmental factors. There are six categories of environmental factors in PESTEL analysis i. e. Political, Economical, Socio–cultural, Technological, Environmental and Legal. (J&S) Secondly this report will look at the Porter’s five forces model for identifying the source of competitors in an industry. (J&S) Findings PESTEL analysis for environmental scanning Political factors †¢ Government stability †¢ Taxation policy †¢ For eign trade regulations †¢ Social welfare policies (Adapted from J&S)Report will show how these political concerns influence alcohol industry. According to Philip Webster and David Rose (The Times, 27. 10. 2005) â€Å"smoking has been banned in all pubs in Scotland and Northern Ireland and now Government is concerning to put a ban on smoking in pubs that serve food in England and Wales†. This new threat will affect the industry’s profitability as it has mentioned in Greene King case study. It will also affect the Government stability. Government is also planning to reduce the consumption of alcohol by putting more taxes on alcoholic drinks.Again it will affect the alcohol industry and prices of alcoholic drinks will rise. If the Government decide to put more tax on alcohol industry then they have to change the policies for tax-free product and also they have to control the black market that offers cheap cigarettes and alcohol. Otherwise new law will not be affectiv e. Therefore companies need to analyse the Government regulations that could jeopardise the profitability and plan for future strategies in order to compete those influences which they could have direct impact on company’s performance.Economical factors †¢ Inflation †¢ Interest rate †¢ Currency fluctuation and exchange rate †¢ Unemployment †¢ Disposal income †¢ Money supply (Adapted from J&S) Companies need to analyse economical factors that affect alcohol industry. For instant if the Government decide to increase the taxes on alcohol industry in order to the alcohol consumption then it will increase the prices of alcoholic drinks. Public’s health is major concerned from the Government prospective but it will affect the companies profitability and their share value.Because high inflation reduces the consumer’s spending power. (According to Greene King case) High interest rate also affects the disposal income. Because it reduces the investment in business and consumer spending power. So it is very important for companies to analyse the economic factors which they could influence the company’s profitability or growth. Socio-cultural factors †¢ Change in lifestyle †¢ Social mobility †¢ Demographic changes †¢ Distribution of income †¢ Education and health (Adapted from J&S) Socio-cultural is another important factor. It needs to analyse continuously.Consumer lifestyle provides opportunities and threats to companies. But it depends how they will tackle them as a valuable opportunity and threat for future strategy. Unequal income distribution also affects the consumer power. So companies need to analyse different level of income and then make their strategy accordingly. Public’s health is an important concern for alcohol industry. Therefore, they need to analyse Government policies on the industry that affect the public’s health. For example in Greene King case Governmen t is more concerned about public health and safety.This is the reason they are planning to increase the taxes in order to reduce the consumption. Another social concern is increased drinking hours that could cause violence and noise. Therefore companies need to analyse those factors to make their future strategies accordingly. Technological factors †¢ Government spending on research †¢ Speed of technology transfer †¢ New development †¢ Government and industry focus on technological effort (Adapted from J&S) The technology factor can influence the companies.It is necessary for companies to make a continuous effort to develop their technologies. It has a direct impact on companies’ performance and could jeopardise the profitability. Companies’ need to analyse external environment for updated their technologies for its future strategies. Sam Smith’s, an owner of chain of pubs, is using CCTV technology. According to company’s spokesman â⠂¬Å"it is much easier to watch every single floor at a same time†. (Greene King case) Environmental factors †¢ Environmental protection law †¢ Waste disposal †¢ Energy consumption (Adapted from J&S)Environmental factors also affect the companies’ reputation and performance. Companies’ should analyse the new environmental law regarding wastage and energy consumption. There are two obvious reasons, public health and environment for government. According to The World Health Organisation â€Å"alcohol is the third- biggest threat to public health† (Greene King case). Resent survey shows that â€Å"10% increase in alcohol prices would cut the alcohol related deaths by 28. 8% for men and 37. 4% for women†. (Greene King case) Legal factors †¢ Monopolies legislation Heath and safety law †¢ Employment law †¢ Product safety (Adapted from J&S) Government is planning to introduce a complete ban on smoking publicly or in social plac es. An industry magazine reports that 42,000 pubs serve food and about 65 per cent of their customers smoke (Webster, P and Rose, D, The Times, 27. 10. 2005). If they continue to serve food then the new regulation could affect their earnings. Greene King’s annual report shows that they are planning to increase the amount of no-smoking floor in their pubs and making out-door areas for smokers.The British Beer and Pub association wants to increase drinking hours. If the Government decided to increase drinking hours, then extra safety and security measure will be required (Greene king case). People will require frequent public transport after social hours to get their destination safely. Government proposal to extant drinking hours will affect employees as well. Its mean they will have to work long hours. Some times new legislation brings new competitors in the market which changed the company’s monopoly in an industry. Porter’s five forces model for environmental scanningThere are five parts of this model. 1. Threat of entry 2. Threat of substitute 3. The power of buyer 4. The power of supplier 5. Competitive rivalry (See appendices for figure 1) Threat of entry â€Å"Threat of entry will depend on the extent to which there are barriers to entry. These are factors that need to be overcome by new entrant if they are to compete successfully†. These barriers include: legislation, economies of scale, capital requirement, distribution channel, experience and relationship with supplier & customers. (J&S, page 113 to 115)In order to compete successfully companies’ need to analyse following barriers: †¢ Cost of capital to enter in an industry with regards to technology and economies of scale †¢ Strong relationship of exiting company with supplier and customer could be costly for new entry †¢ Product differentiation or high quality services could give competitive advantage or barrier †¢ Existing high experienced comp anies could take an advantage in terms of cost, customers and supplier loyalty †¢ Threats of Government policies †¢ Changes in technology would affect the competitive advantage (Source adapted from J&S page 113 to 115)Threat of substitutes â€Å"Substitution reduces demand for particular ‘class’ of product as customer switch to the alternatives. † (J&S, page 115) Threats of substitutes work when other companies provide the same product with more benefits and value. Therefore companies need to develop their products by analysing their environment. A Victorian style of pub is a good example where customers can have smoking and non-smoking floor separately. The power of buyers Buyers power likely to be high when customers could get same product at low price from different suppliers.Buyer will have more bargaining power when switching cost from one supplier to another is low. In order to reduce the buyer’s power company’s needed to develop the ir products. So they could offer more benefits and value. (Adapted from J&S) For example if Government decided to increase tax on alcoholic drinks in order to reduce the crime and consumption rates then this impact reduce the company’s sales. Longer drinking hours will increase the buyer’s power in terms of alternative. It’s necessary for companies’ to analyse those factors so they can reduce bargaining power. The power of supplier Supplier power likely to be high when: Limited sources and suppliers are available †¢ High switching cost from one supplier to another †¢ Different quality or services from alternative †¢ Powerful brand of supplier (Adapted from J&S) Analysis of these factors can increase bargaining power with supplier. I. e. change in tax policy could affect the supplier’s power. In other word if Government increased the taxes on alcoholic drinks then whole production cost will change. Because supplier will charged extra and as result prices of alcoholic drinks will raise. Competitive rivalry â€Å"Competitive rivals are organisation with similar product and services aimed at same customer group†. Adapted from J&S, page 118) Factors affecting competitive rivalry †¢ High fixed cost of products may increase price war †¢ Customer could switch to other competitor if products are undifferentiated. †¢ High exit barriers could lead to increased in competition because of high investment in non-transferable fixed assets or high redundancy cost †¢ Competitors are in balance-roughly equal size – lead to higher rivalry (Adapted from lecture note 2, 5. 10. 2005 and J&S) Therefore companies need to analyse those factors which are affecting on competitive rivalry. If they do not keep an eye on them then growth of company will be affected.Industry consolidation in light of the Greene King experience Industry consolidation in the light of Greene king experience is very successful. A ccording to the case study, Greene king is the British pubs and brewery group based in Suffolk. Since 1996 they have acquired 1,600 pubs (See appendices figure 2 for Greene king’s acquisitions experience). Now they are taking over Scotland’s oldest brewery company ‘Belhaven’ and Essex based brewery & pubs group ‘Ridley’. Greene King has an opportunity to enter in a competitive market and expend their operations across UK.Greene king has a large distribution channel, 2,064 owned pubs which can sell their own brewed drinks. Industry consolidation reduces per unit cost of product because of the mass production and increases the profitability. Consolidation also reduces the supplier power and increase the bargaining power with supplier. It also increases the wealth of shareholders. Small company has got benefit from being part of large company and has a chance to sale their drinks in new market. It’s a good step for small companies to devel op their businesses for the future. Consolidation reduces the competition in an industry and creates more jobs. Greene king case) Conclusion Environmental analysis gives better understanding for decision making and help to make positive strong future strategies. In order to competing environmental influences companies’ need to analyse their environment on continuous basis. Consolidation of industry is cost effective and has wide horizon of competitive market. It also increases the interest of stakeholders. Recommendation Companies need to analyse their internal or external environment on regular basis. This report highly recommends the PESTEL analysis and Porter’s five forces model for environmental analysis. These models help in decision making and company’s future growth.References †¢ Greene King annual report 2004 & 2005, access date: 20. 10. 2005 and 01. 11. 2005. www. greeneking. co. uk †¢ Johnson, G and scholes, k (2002), Exploring Corporate Stra tegy 6th ed UK: Prentice Hall. †¢ Webster, P and Rose, D (2005) â€Å"Pubs will call time on food to keep smokers† in The Times newspaper, 27. 10. 2005, page 1 and 9. †¢ Wiscarson, G, Strategic Environment, Lecture notes 1, 28. 09. 2005. †¢ Wiscarson, G, Strategic Environment, Lecture notes 2, 05. 10. 2005.

Mother to Son and the Coora Flower: a Poetry Analysis

Mother to Son and The Coora Flower: A Poetry Analysis In poetry, more so than any other form of literature, understanding sound, meaning and theme are key to understanding the work itself. In the case of the poems â€Å"Mother to Son† by Langston Hughes and â€Å"The Coora Flower† by Gwendolyn Brooks these elements, when heavily focused upon, allow the reader to discover the message that these writers were attempting to convey.Thought both writers use these elements to their fullest to communicate their respective messages, the method and messages vary greatly. In the poem Mother to Son, Hughes tells the tale of a mother speaking to her son about life and the hardships that one must face to make it in the world. Hughes uses extended metaphor to establish this view. In the second line he writes â€Å"Life for me ain’t been no crystal stair†, which initiates the metaphor.He then proceeds to describe the stair of her life. With the lines, â€Å"It’s h ad tacks in it, and splinters, and boards torn up, and places with no carpet on the floor†¦Ã¢â‚¬  he support the mothers claim that like has not been a crystal stair case by using the metaphor to make a direct comparison between imperfections in the staircase and the pitfalls in life. He continues on with the line â€Å"bare† symbolizing rock bottom, nothingness, the absence of value.Then poem then begins to rise in action to signify the continued climb and the need to continue on, which is seen in the following lines; â€Å"I’se been a-climbin’ on,/ and reachin’ landin’s,/ and turnin’ corners,/ and sometimes goin’ in the dark†¦Ã¢â‚¬  the narrator states to the son once more that they still continue to climb and that life was easy for them. The language and the line structure chosen by Hughes help facilitate the message. He use very simple language but is able to invoke strong emotions from the reader.The language would p otentially lead the reader to believe that this is truly a simple woman who had to struggle everyday of her life to make it. If Hughes had used more formal language within the work I do believe the mood would have been lost. The use of â€Å"And† at the beginning of lines creates almost a stepping motion within the rhythm of the words. Lines four, five and six in conjunction with the use of â€Å"And† creates a feeling of stepping or maybe even falling down stairs. Each lines description gets progressively worse until there is nothing left, which signified having nothing left to lose.Then with lines ten, eleven and twelve the use of â€Å"And† creates the sense of climbing back up with the same speed at which you fell. Line twelve ends the climb in sound and creates a leveling off that coincides with the walk through the dark stated in the poem. This established a mood of cautiousness, feeling things are. I thought this was a perfect example of theme and sound c oming together to support meaning. I especially like the lines, â€Å"Don’t you set down on the steps. / ‘Cause you find it’s kinder hard. It shows that giving up isn’t an option; that quitting is the easy way out and that continuing to struggle on and fight is what’s really difficult. She asks no more of the son than she would ask of herself because she knows that it can be done, she was able to accomplish it herself. In Brooks’ poem The Coora Flower, she writes about escapism and reality. The poem starts off with the narrator telling the reader what she learned about and then we are snatched back into reality with the lines, â€Å"Now I am coming home. / This, at least, is Real, and what I know.The following stanzas construct the comparison between life in school which is the escape and the life outside which is reality; â€Å"It was restful, learning nothing necessary. / School is a tiny vacation. At least you can sleep†¦/ But now it’s Real Business. I am Coming Home. † And as we read on we discover that reality is harsh, cold, painful and unrelenting and that the other world is more optimistic, warm and liberated. â€Å"My mother will be screaming in an almost dirty dress. / The crack is gone. So a Man will be in the house. / I must watch myself. / I must not dare to sleep. These lines define reality within the poem. Brooks also relies heavily on nuances within the structure and language to establish the message. The stanzas that contain information about school are longer and articulate. The lines flow and are inviting. When the lines about reality are read they are short, cold and very deliberate; they give a sense of rigidity. The language is very direct and in some case demanding â€Å"I must†¦Ã¢â‚¬ . All stanzas about what’s â€Å"real† are two lines long while the ones that focus on school are four lines long. The statements toward school came off as being very cynica l to me. It was restful, learning nothing necessary†¦ At least you can sleep†, the use of â€Å"at least† in these lines and the line that follows are what created the cynicism for me. It seemed as if she didn’t respect what went on in school because it wasn’t the harshness of her everyday life. Capitalization is something that caught my attention. The word â€Å"Real† always has the first letter capitalized, which to me established a mood of seriousness within the statements that contained it. I feel this is true the second use of â€Å"Coming Home† and â€Å"Man† in line fourteen.The capitalization on these words was carefully chosen to continue facilitating the theme and meaning. There is one line in this poem that caught my attention and required me to reread repeatedly to get what she truly meant that line is â€Å"which is not free from grief†. At first I thought it was just in reference to the previous line â€Å"At least you can think of love or feeling your boy friend against you† but upon multiple readings I realized that this was in reference to the whole stanza. She’s hinting at the fact that even good things come with their element of heartache.I found that to be an interesting idea and it shows that the narrator may never be able to find peace, maybe she thrives on the hardship and anguish that comes with her life because that is all she knows. When the two works are placed side by side one would have a hard time make a connection between them. It is true that the differences between the works are great but elements exist in both; some minor, some major but all important. One could make the simple connection both individual were African- American doesn’t give them the respect they deserve.Also that connection would have to be made off historical references outside of the work because nothing in either work given you indication that they are African American. The conn ection that should be made is that the both wrote of adversity and hardship; that both used elements like structure, language, tone to convey their message but end the came out with very different view points. From a psychological perspective the reader can focus on the fact that in Hughes’ poem the adversity within it was deemed to be external to the one relationship shown.In the case of Brooks the adversity was internal to the shown relationship. In both situations the writers own their material, you get the sense that these works are true to life for both of them. But where Hughes’ work is empowering, Brooks’ work is saddening because you can’t see the light at the end of the tunnel for her narrator you just she the cold, harsh reality that is life, which was her intention. Her story was never meant to be uplifting it was meant to depress and sadden. Even in her few moments of joy, the narrator still could be happy because she knew at any moment it cou ld all end.Both writers are successful at establishing a mood and theme throughout there works. I believe if these writers had an opportunity to sit down with either they would see elements of themselves in the other. In one case the young and still hopefully individual and in the other harden and scared individual that the young may become. But in the end these are my interpretations and it up to you to make your own. That’s the wonderful part about poetry it’s different for everyone who reads it.

Immunology

Introduction to IMMUNOLOGY COURSE †¢ Subject Agenda* Theoretical part (Lecture): 14. 01—-18. 03—-22. 04. 2013 Practical part (Labwork) †¢ Study Materials: Textbook (David Male and Ivan Roitt-2006-DIR; Abul Abbas-2007AA), Clips and Internet search †¢ [email  protected] com. Pass: btiu12345 †¢ Evaluation – Midterm Exam, Final Exam, Labwork – Assignment (Home-work, Topic-oriented-In-class discussion, Readand-Present Practice) Contact me at: R501, IU Building; or via email: [email  protected] edu. vn NTTH-HCMIU-IMMUN-2013 Introduction to IMMUNOLOGY- An X soup What is Immunology? What is Immune System (IS)? †¢ History of Immunology †¢ Cells and Soluble Mediators of IS= ? †¢ Immune Response- Pathogens (Ags): Innate and Adaptive Immunity- Collaboration NTTH-HCMIU-IMMUN-2013 Introduction to IMMUNOLOGY What is Immunology? What is Immune System (IS)? Immunology is the study of our protection from foreign macromolecules or invad ing organisms and our responses to them. Foreign macromolecule/ Antigen –— Immunogen: e. g. virus protein, worm, parasite Everything that should not be in my bodyImmune System: Molecules, cells, tissues and organs which provide nonspecific and specific protection against Microorganisms; Microbial toxins and Tumor cells Crucial to human survival NTTH-HCMIU-IMMUN-2013 History of Immunology †¢ Experiential Immunology period †¢ Experimental Immunology period †¢ Modern Immunology period Immunology act as an independent subject (1970s) NTTH-HCMIU-IMMUN-2013 I. Experiential Immunology period (the 17th century- the middle of 19th century) In ancient times, many serious infection diseases, such as smallpox, plague and cholera etc, caused innumerable people dead.Plague !!! — Black Death Disease NTTH-HCMIU-IMMUN-2013 Story of Plague port of Weymouth. The Black Death was one of the most devastating pandemics in human history, peaking in Europe between 1348 an d 1350, and killing between 75 million and 200 million people Wikipedia Yersinia pestis NTTH-HCMIU-IMMUN-2013 Figure 1. Photomicrographs demonstrating the high bacterial burden of Y pestis in various organs. Top left, A: Tissue Gram stain of a lymph node reveals the profusion of neutrophils and large clumps of Gram-negative coccobacilli characteristic of Y pestis (Brown-Hopps, original ? 00). Large clusters of bacteria (arrows) are found in the alveolar spaces (top right, B), adrenals (bottom left, C), and kidneys (bottom right, D) [hematoxylin-eosin, original ? 400]. Chmura et al. 2003, CHEST, Painful Lymphadenopathy and Fulminant Sepsis in a Previously Healthy 16-Year-Old Girl NTTH-HCMIU-IMMUN-2013 ~ 430 B. C: Peloponesian War, Thucydides describes plague – the ones who had recovered from the disease could nurse the sick without getting the disease a second time NTTH-HCMIU-IMMUN-2013 In 1670, Chinese medical practitioners : variolationEdward Jennar —-An English physi cian He discovered that cowpox vaccination protected against smallpox in 1796 NTTH-HCMIU-IMMUN-2013 Vaccine- Vaccination Vaccine: A preparation of microbial antigen, often combined with adjuvants,that is administered to individuals to induce protective immunity against microbial infections. Vaccination: A general term for immunization against infectious diseases,orginally derived from immunization against smallpox which uses the Vaccinia virus. NTTH-HCMIU-IMMUN-2013 NTTH-HCMIU-IMMUN-2013 Why do they not want to play with my kids? NTTH-HCMIU-IMMUN-2013 II.Experimental Immunology period (the middle of 19th century-the middle of 20th century) 1. Active immunity In the middle of 19th century R. Koch —-Isolated and cultured bacteria successfully Pasteur —-Infectious diseases were caused by pathogens In 1880, Pasteur —-Anti-cholera live-attenuated vaccine (old culture of Chicken V. cholera) —-Artificial active immunity Robert Koch Active immunity: The form of a daptive immunity that is induced by exposure to a foreign antigen and in which the immunized individual plays an active role in responding to the antigen. Louis Pasteur(1822-1895) NTTH-HCMIU-IMMUN-2013 . Passive immunity In the late eighties of 19th century Roux and Yersin: Diphtheria was caused by exotoxin produced by C. diphtheriae The discovery of diphtheriae antitoxin and bactericindins Antitoxin—-Antibody (Ab); Exotoxin—-Antigen (Ag) Study on reaction of Ag and Ab in vitro —-Serology In 1890,Von Behring and Kitasato —-diphtheriae antitoxin was applied in treatment of Diphtheria —- Artificial passive immunity Passive immunity: The form of immunity to an antigen that is established in one individual by transfer of antibody or lymphocytes from another individual who is immune to that antigen.NTTH-HCMIU-IMMUN-2013 3. Mechanism of protective immunity Cell mediated immunity(CMI) —–1883-1884, Metchnikoff: Microorganisms were engulfed an d destroyed by phagocytic cells Humoral immunity(HI) —-1897,Ehrlich: Ab in serum played important roles in protective immunity Both HI and CMI were very important for protective immunity, Ab in serum could promote the phagocytosis of phagocytic cells —- 1903, Wright & Douglas 4. Study on immune-pathology & immune disease In 1902, Richet and Portier—-Anaphylaxis Pirquet and Shick—-Hypersensitivity In 1903,Arthus—-Arthus phenomenon In 1906, Pirquet —- Allergy In 1907, Donath and Landsteiner —-Autoantibody cause autoimmune disease NTTH-HCMIU-IMMUN-2013 5. Study on antigen In the early of 20th century, Landsteiner studied on antigenic determinant (epitope) —-ABO blood type 6. Study on immunochemistry In 1938,Tiselius and Kabat —-Ab is ? globulin In the fifties of 20th century, Porter and Edelmen, —-Molecular structure of Ab: 4 peptides 7. Study on immune tolerance: No positive response to specific Ag In 1945, Oven fou nd natural immune tolerance In 1953, Medawar set up animal model of acquired immune tolerance in newborn period. . Hypothesis for Ab formation Templates postulate (1930,Breinl and Haurowitz) Variable folding postulate (1940,Pauling) Natural selection postulate (1955,Jerne) Clonal selection theory (1959, Burnet):- Clone: a group cells that stem from identical cell NTTH-HCMIU-IMMUN-2013 III. Modern Immunology period (the middle of 20th century-the 21th century) 1. Study on immune system In 1957, Glick Fabricius found out that Chicken without bursa can not produce Ab —-B cell In 1961,Good and Miller —- Cell mediated immune of new born mice whose thymus were taken away are defective —-T cell 2.Study on monoclonal antibody —-In 1975, Kohler and Milstein 3. Study on immune genetics —-In 1978, genetic control of antibody diversity —-Discovery of accurate mechanism of immune response on gene level (MHC, TCR , BCR) 4. Study on molecular mechanism of T/B lymphocyte activation and signal transduction 5. Study on effective mechanism of immune cells NTTH-HCMIU-IMMUN-2013 6. Study on clinical immunology Organ transplantation; Autoimmune disease; Tumor immunology; Infectious diseases 7.Study on applied immunology Preparation of monoclonal antibody and genetic engineering antibody; Preparation of recombinant cytokines; Study on DNA vaccine; Study on treatment with immune cells 8. New techniques of modern immunology and application Separation of immune cells; Protein analysis technique; Phage display technique; Preparation of new animal model NTTH-HCMIU-IMMUN-2013 NTTH-HCMIU-IMMUN-2013 NTTH-HCMIU-IMMUN-2013 The immune system Immune system Innate (non-specific) immunity Adaptive (specific) immunity Anatomic barriers (Skin,mucous membranes) †¢Physological barriers (temperature, pH) †¢Phagocytic Barriers (cells that eat invaders) †¢Inflammatory barriers (redness, swelling, heat and pain) †¢Antigen specificity †¢Di versity †¢Immunological memory †¢Self/nonself recognition NTTH-HCMIU-IMMUN-2013 Our immune systems generate an almost infinite variety of cells and substances Foreign Recognition Memory Upon 2 ° exposure produces enhanced response Effector Response To eliminate or neutralize particle *In some cases, the IR fails to function; at other times, the IR can turn on its hostNTTH-HCMIU-IMMUN-2013 Humoral and cellular immunity (antibody mediated or cellular) NTTH-HCMIU-IMMUN-2013 B cells Surface bound antibody Antibody secreting B cell Antigen B-cell Soluble antibodies, circculate in the body NTTH-HCMIU-IMMUN-2013 Antibody secreting B cell B-cell Virus killed NTTH-HCMIU-IMMUN-2013 Discussion Topics 1. Why do warm-blooded, long-lived animals require particularly complex immune defense? – p4-DIR 2. Why would removal of Ag lead to the decline in an immune response? – p14-DIR And many more to explore in the DIR textbookHome works P18-DIR NTTH-HCMIU-IMMUN-2013 The real o nes Crawling Macrophage Neutrophil and DCs NTTH-HCMIU-IMMUN-2013 Introduction to IMMUNOLOGY- An X soup †¢ What is Immunology? What is Immune System (IS)? †¢ History of Immunology †¢ Cells and Soluble Mediators of IS= ? †¢ Immune Respone- Pathogens (Ags): Innate and Adaptive Immunity- Collaboration Read DIR-page 1-18 NTTH-HCMIU-IMMUN-2013 Once upon a time†¦ There was a WARGAMES OF THRONES- MATTER OF â€Å"LIVE OR DIE† HAS IT ALREADY ENDED? NO, IT IS JUST A BEGINNING†¦ NTTH-HCMIU-IMMUN-2013